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Pragmatic trials are those that are designed to provide information for the real-world practice of clinical. They are often characterized as focusing on practical aspects of designing a study that include the recruitment and consent process, as well as adherence and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could lead to issues with the design of the trial.
Pragmatic Play Pragmatic Play, one of the biggest players on the live casino market offers an array of traditional table games like Blackjack and Roulette. The company's live studios in Romania and Malta offer a real-life gambling experience for customers, as well as a full suite of virtual betting options. The company has also created numerous interactive game shows that make gambling online enjoyable. Some of these shows are hosted live, while others include famous people from the industry.
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Pragmatic trials aim to mimic real-life settings and achieve maximum external validity. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can be used to determine the causality of an intervention with its outcomes. However, they shouldn't be used to substitute for the use of explanation trials.
The pragmatism idea is controversial, and there are questions about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials that inform the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a practical study which includes the recruitment, design, and delivery of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This is an indication that the health science community is becoming more acquaint to the subject of pragmatism. However, it is important to remember that the majority of these studies were conducted in primary care settings.